I HATE SPYWARE!!!!

you know this spyware thing is really pissing me off. i run a scan practically everyday and everyday there is about 20 to 40 critical items found in system. and today my system been effected by it and i can't seem to remove it, i've used every means possible and still when i open my internet explorer, i get some search website as my home page. even after changing my default website at the internet options. this sucks....any idea what else to do?? i'm up for any suggestions, including blowing my brains out!!!